Guan Shuang is a Professor in the Department of Food Science and Engneering at Jilin University in Jilin Province, China. Guan received his Ph.D. in Veterinary Pharmacology from Jilin University, and also holds a M.D. in Food Science. Dr. Guan research program is focused on toxicity mechanism of food contamination, the effects of functional foods/nutraceuticals/bioactive compounds in natural products and herbal on lipid metabolism. In recent years, he has presided over or participated in a number of provincial and ministerial scientific research projects and enterprise projects.Up to now, more than 35 peer-reviewed research papers have been published in academic journals as the first author or corresponding author.
Email： 907761215@qq.com; guan_shuang22@jlu.edu.cn
Education
2013.03-2013.11，Conell University，Food Science, Visit scholar
2011.12，JiLin University，Veterinary Pharmacology, Ph.D
2009.07，JiLin University，Food Science and Engineering, M.D.
Working Experience
2020.10-Now，Professor, College of Food Science and Engineering, Jilin University
2015.10-2020.09，Vice Professor, College of Food Science and Engineering, Jilin University
2012.03-2015.09，Lecturer, College of Food Science and Engineering, Jilin University
Recently projects
1.1,3-dichloro-2-propanol induced lipid accumulation by inhibiting autophagy in hepatocytes. National Natural Science Foundation of China.NO. 32072315, 2021-2024 58万元；
2.Identification and mechanisms of natural compounds against type III secretion
systems of Salmonella enterica Typhimurium. National Natural Science Foundation of China, 2017-2021 149.75万元；
Courses
Food toxicology, Food immunology, Food quality and safety
Recently articles
Jing Lu，Jianing Lu , Yan Chen, Zhe Feng, Guan Shuang(*). 1,3-dichloro-2-propanol induced lipid accumulation by blocking autophagy flux in HepG2 cells. TOXICOLOGY. 454(2021):152716.
Jing Lu，Jianing Lu , Yan Chen, Zhe Feng, Shuang Liu, Guan Shuang(*). 3-Chloro-1, 2-propanediol inhibits autophagic flux by impairment of lysosomal function in HepG2 cells. FOOD AND CHEMICAL TOXICOLOGY. 2020(144):111575.
Jing Lu, Zhuoqun Meng, Yan Chen, Liangli Yu,,Boyan Gao, Yangjie Zheng, Guan Shuang(*). Apigenin induced autophagy and stimulated autophagic lipid degradation. Food & Function.2020, DOI: 10.1039/d0fo00949k
Shuang Guan , SiYu Tao, YiXuan Huang, YingLi Jin, YuTing Hu, Jing Lu. Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux. Ecotoxicology and Environmental Safety. 2020(205)111062.
Carbon black-benzo(a)pyrene complex-induced apoptosis and autophagy blockage in rat alveolar macrophages. TOXICOLOGICAL & ENVIRONMENTAL CHEMISTRY. 2020.05
Apigenin reduces the excessive accumulation of lipids induced by palmitic acid via the AMPK signaling pathway in HepG2 cells. EXPERIMENTAL AND THERAPEUTIC MEDICINE 18: 2965-2971, 2019
Cheng, BJ; Lu, J ; Li, TJ ; Meng, ZQ ; Liu, MT; Guan Shuang(*). 1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells. FOOD AND CHEMICAL TOXICOLOGY. 2018(122):143-150
Lu J, Cheng B, Meng Z, Fang B, Li T, Sun M, Liu M, Guan Shuang(*). Alliin attenuates 1, 3-dichloro-2-propanol-induced lipogenesis in HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway.Life Sci. 2018 Feb 15;195:19-24.
Lu J, Cheng B, Fang B, Meng Z, Zheng Y, Tian X, Guan Shuang(*). Protective effects of allicin on 1,3-DCP-induced lipid metabolism disorder in HepG2 cells.Biomed Pharmacother. 2017 Dec;96:1411-1417.
Lu J, Fang B, Zheng Y, Yu X, Huang G, Wang Z, Deng X, Guan Shuang(*).1,3-dichloro-2-propanol induced lipid accumulation in HepG2 cells through cAMP/protein kinase A and AMP-activated protein kinase pathways via Gi/o-coupled receptors.Environ Toxicol Pharmacol. 2017 Oct;55:118-126.
Guan, Shuang ; Zheng, Yiying; Yu, Xin; Lu, Jing. Ellagic acid protects against LPS-induced acute lung injury through inhibition of nuclear factor kappa B, proinflammatory cytokines and enhancement of interleukin-10. FOOD AND AGRICULTURAL IMMUNOLOGY,2017:28(6):1347-1361
Guan, Shuang ; Yu, Xin; Fang, Baochen; Lu, JingThe toxicity of 3-monochloro-1,2-propanediol (+) to activated T cells in mice. AGRICULTURAL IMMUNOLOGY:28(4):612-624.
Guan S, Huang Y, Feng Z, Xu L, Jin Y, Lu J. The toxic effects of benzo[a]pyrene on activated mouse T cells in vitro. Immunopharmacol Immunotoxicol. 2017 Jun;39(3):117-123.
Lu J, Wang Z, Ren M, Huang G, Fang B, Bu X, Liu Y, Guan Shuang(*).Antibacterial Effect of Gallic Acid against Aeromonas hydrophila and Aeromonas sobria Through Damaging Membrane Integrity.Curr Pharm Biotechnol. 2016;17(13):1153-1158.
Jin Y, Wang Y, Zhao D, Ma S, Lu J, Guan Shuang(*).Pristimerin attenuates ovalbumin-induced allergic airway inflammation in mice.Immunopharmacol Immunotoxicol. 2016 Jun;38(3):221-7
Concentration of Omega-3 Polyunsaturated Fatty Acids from Rana Egg Oil by Urea Complexation and Response Surface Methodology. American Journal of Food Technology 2016.04
